Our Mission and Vision

The CLUSTER Consortium – Childhood arthritis and its associated uveitis: stratification through endotypes and mechanism to deliver benefit

CLUSTER Sustainability  

 

The CLUSTER Consortium is a 5-year Medical Research Council project, funded until summer 2023. We want to make long term impacts on the treatment of JIA and JIA-uveitis. On this page, you can learn about how we plan to do this through Our Mission, Our Vision and how we plan to do this.

 

 

CLUSTER's Mission

 

Mission :  To improve health outcomes in JIA by advancing the care of patients with arthritis and uveitis through understanding of disease mechanisms and outcomes.

“Cluster works as a team. Clinicans and scientists from diverse fields with patients and families build the research together with immense vision and energy and hope for the future”

Professor Andrew Dick, CLUSTER Co-Investigator

Director of UCL-Institute of Ophthalmology and Duke-Elder Chair, UCL. London. Professor of Ophthalmology, University of Bristol

CLUSTER's Vision

 

Vision : Develop new understanding and classification of disease, by development of tools that help to predict disease course and likely response to medicines, ultimately leading to development of new and personalised therapies for JIA (arthritis and uveitis). This will be achieved by multidisciplinary working with experts, applying the best methods for research, such as artificial intelligence, to make the most of the biomedical data revolution. This will all be done with patients at the heart of research, ensuring that our research is open and explainable to all.

How will we achieve this?

 

We do this by:

Working with exceptional researchers and clinicians

Being collaborative and multidisciplinary

Making data findable, accessible, interoperable and reusable to speed up and maximise research impact globally

Developing careers

Working as a community of patients/Carers/Industry/Charities/NHS and academia

“Often patients haven’t been told what their data is used for in research, but this is changing with projects such as CLUSTER, where patients are seen as partners throughout the journey.”
Eilean McDonald, CLUSTER Champion and patient of JIA

Groundbreaking new study on potential new disease targets

  Groundbreaking new study on potential new disease targets Until this study, researchers had only examined blood samples and fluid from the joints of children with juvenile idiopathic arthritis (JIA). In this study, to better understand how JIA affects joints at...

Versus Arthritis’ Research Highlight of the Year: Vote for CLUSTER!

CLUSTER researchers have been shortlisted for the Versus Arthritis Research Highlight of the Year Award! Huge congratulations to Dr Melissa Tordoff, Dr John Bowes and team based at University of Manchester for leading this fantastic paper “Integration of Genetic and...

Understanding the Genetic Factors of Uveitis: Paving the Way for Predictive Screening Tools

New Uveitis research from the CLUSTER Consortium has shown that combining genetic and clinical information could predict which people with juvenile idiopathic arthritis (JIA) are more likely to develop uveitis (JIAU) – a co-occurring condition of JIA which involves...

CLUSTER Researcher Stephanie Shoop-Worrall presents at PReS YIM 2024

Stephanie Shoop-Worrall presented work from a EULAR-funded international collaboration at the PReS YIM This work was figuring out which tool should be used to measure disease activity in adults with JIA. She showed that a tool developed for children and young people...

CLUSTER Champions write rapid response letter to BMJ

The CLUSTER Champions respond to BMJ article on PPIE through a rapid response letter.  CLUSTER Champions respond to BMJ article, The patients bringing lived experience to research teams | The BMJ, echoing support for finding more ways for patients and researchers to...

CLUSTER Consortium Celebrate 6+ Years of successful collaborative research

The CLUSTER Consortium, a UK wide partnership with aims of improving care of young people with JIA and its associated eye condition uveitis, recently celebrated over six years of research addressing the needs of children and young people with arthritis.

Dr Stevie Shoop-Worrall awarded ‘Inclusive PPIE Award’ at University of Manchester Patient and Public Involvement and Engagement (PPIE) Celebration

The University of Manchester recently held a Patient and Public Involvement and Engagement (PPIE) Celebration on the 11th of July, titled ‘Back to the future: reflecting on our past, shaping our tomorrow’. At this event Dr Stevie Shoop-Worrall, CLUSTER Researcher and active collaborator with the CLUSTER Champions, was awarded the Inclusive PPIE winner (read more here).

Embedding the patient experience in the next generation of JIA research

Last week we welcomed researchers from across the UK, from PhD students to early career group leaders for a day focused on one vital aspect of research: the patients. This event co-designed and delivered by our dedicated parent and patient group, The CLUSTER...

BSR 2023: The Future in Paediatric Rheumatology Research Looks Bright!

    The British Society for Rheumatology Annual Conference, #BSR 2023, drew to a close at the end of last month and the jam packed agenda did not disappoint. We were delighted to see CLUSTER represented by several speakers, who celebrated the Consortium’s...

CLUSTER Champions come together for a day of strategy and celebration!

Photo credit @Dauda Bappa Our wonderful CLUSTER Champions came together last week for our first in-person meeting since the COVID pandemic. The day was filled with enthusiasm and ideas as our Champions discussed their priorities for the remainder of the project,...

CLUSTER is one of the MRC funded consortia

looking into stratified medicine of juvenile idiopathic arthritis.

For more information, see the MRC website using the following link:

 

 

Consortia

https://www.ukri.org/what-we-offer/browse-our-areas-of-investment-and-support/precision-medicine/